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Article

Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.

The Journal of biological chemistry - 30 Mar 2012

Forsberg Maud, Holmborn Katarina, Kundu Soumi, Dagälv Anders, Kjellén Lena, Forsberg-Nilsson Karin

Abstract excerpt

Heparan sulfate proteoglycans, present on cell surfaces and in the extracellular matrix, interact with growth factors and morphogens to influence growth and differentiation of cells. The sulfation pattern of the heparan sulfate chains formed during biosynthesis in the Golgi compartment will determine the interaction potential of the proteoglycan. The glucosaminyl N-deacetylase/N-sulfotransferase (NDST) enzymes...

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Source

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Identifiers

PMID: 22298785
DOI: 10.1074/jbc.M111.337030
PMCID: PMC3322844

Genes

NDST1
NDST2
FGF2
FGF4
GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.PMID 22298785Read ↗

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Heparan Sulfate Enhances the Self-Renewal and Therapeutic Potential of Mesenchymal Stem Cells from Human Adult Bone MarrowSemantic proximity Read ↗

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