Article
The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita.
The Journal of pathology - 1 Sept 2015
Sadeghi Hengameh, Gupta Yask, Möller Steffen, Samavedam Unni K, Behnen Martina, Kasprick Anika, Bieber Katja, Müller Susen, Kalies Kathrin, de Castro Marques Andreia, Recke Andreas, Schmidt Enno, Zillikens Detlef, Laskay Tamás, Mariani Jean, Ibrahim Saleh M, Ludwig Ralf J
Abstract excerpt
Genetic studies have added to the understanding of complex diseases. Here, we used a combined genetic approach for risk-loci identification in a prototypic, organ-specific, autoimmune disease, namely experimental epidermolysis bullosa acquisita (EBA), in which autoantibodies to type VII collagen (COL7) and neutrophil activation cause mucocutaneous blisters. Anti-COL7 IgG induced moderate blistering in most inbred...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.