Article
R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history.
Pathology oncology research : POR - 1 Dec 2010
Eren Fatih, Akkiprik Mustafa, Atuğ Ozlen, Sönmez Ozgür, Tahan Gülgün, Ozdemir Filiz, Hamzaoğlu Hülya Over, Celikel Ciğdem Ataizi, Imeryüz Neşe, Avşar Erol, Ozer Ayşe
Abstract excerpt
P53 tumor suppressor protein is one of the pivotal regulators for genome integrity, cell cycle and apoptosis. The most commonly and extensively studied single nucleotide polymorphism (SNP) of p53 is Arg>Pro substitution on codon 72 (R72P). Although we know that the SNP has unique functional effects on the protein, its clinical significance is not clearly identified yet. Aim of the study was to access the...
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