Article
Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats.
Biochemical and biophysical research communications - 17 Feb 2012
Asahina Makoto, Mashimo Tomoji, Takeyama Michiyasu, Tozawa Ryuichi, Hashimoto Tadatoshi, Takizawa Akiko, Ueda Masatsugu, Aoto Toshihiro, Kuramoto Takashi, Serikawa Tadao
Abstract excerpt
To establish low density lipoprotein receptor (LDLR) mutant rats as a hypercholesterolemia and atherosclerosis model, we screened the rat LDLR gene for mutations using an N-ethyl-N-nitrosourea mutagenesis archive of rat gene data, and identified five mutations in its introns and one missense mutation (478T>A) in exon 4. The C160S mutation was located in the ligand binding domain of LDLR and was revealed to be...
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