Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ApoE Receptor-2 R952Q Variant in Macrophages Elevates Soluble LRP1 to Potentiate Hyperlipidemia and Accelerate Atherosclerosis in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2025

Turkson Vanessa, Haller April, Jaeschke Anja, Hui David Y

Abstract excerpt

BACKGROUND: apoER2 (apolipoprotein E receptor-2) is a transmembrane receptor in the low-density lipoprotein receptor (LDLR) family with unique tissue expression. A single-nucleotide polymorphism that encodes the R952Q sequence variant has been associated with elevated plasma cholesterol levels and increased myocardial infarction risk in humans. The objective of this study was to delineate the mechanism underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Diseases
Share to Bone Marrow Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Hyperlipidemias

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to p38 Mitogen-Activated Protein Kinases

Share to Plaque, Atherosclerotic

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 39508104
DOI: 10.1161/ATVBAHA.124.321748
PMCID: PMC11668615

Genes

LDLR
LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ApoE Receptor-2 R952Q Variant in Macrophages Elevates Soluble LRP1 to Potentiate Hyperlipidemia and Accelerate Atherosclerosis in Mice.PMID 39508104Read ↗

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.Semantic proximity Read ↗

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.Semantic proximity Read ↗

LRG1 promotes atherosclerosis by activating macrophagesSemantic proximity Read ↗

Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor.Semantic proximity Read ↗

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.Semantic proximity Read ↗

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.Semantic proximity Read ↗

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.Semantic proximity Read ↗

Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype.Semantic proximity Read ↗

Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia.Semantic proximity Read ↗

ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesisSemantic proximity Read ↗

LAMB2 p.E991K Mutation-Mediated Atherosclerosis in Rabbit.Semantic proximity Read ↗

Mouse models of hyperlipidemia and atherosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.