Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells.

Aging - 1 Jan 2012

Altilia Serena, Santoro Aurelia, Malagoli Davide, Lanzarini Catia, Ballesteros Álvarez Josué Adolfo, Galazzo Gianluca, Porter Donald Carl, Crocco Paolina, Rose Giuseppina, Passarino Giuseppe, Roninson Igor Boris, Franceschi Claudio, Salvioli Stefano

Abstract excerpt

Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution. The two resulting p53 isoforms have a different subcellular localisation after stress (more nuclear or more mitochondrial for the P or R isoform, respectively). p53P72 variant is more efficient than p53R72 in inducing the expression of genes involved in nuclear DNA repair. Since p53 is involved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Protein Isoforms
Share to 8-Hydroxy-2'-Deoxyguanosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyguanosine

Share to DNA Damage

Share to DNA, Mitochondrial

Share to HCT116 Cells

Share to Protein Transport

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 22289634
DOI: 10.18632/aging.100425
PMCID: PMC3292903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells.PMID 22289634Read ↗

Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.Semantic proximity Read ↗

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.Semantic proximity Read ↗

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.Semantic proximity Read ↗

p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1.Semantic proximity Read ↗

Variation in the human TP53 gene affects old age survival and cancer mortality.Semantic proximity Read ↗

The Codon 72 Polymorphism of p53 Regulates Interaction with NF-κB and Transactivation of Genes Involved in Immunity and InflammationSemantic proximity Read ↗

Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer.Semantic proximity Read ↗

TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population.Semantic proximity Read ↗

The codon 72 polymorphic variants of p53 in Italian rheumatoid arthritis patients.Semantic proximity Read ↗

The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.Semantic proximity Read ↗

The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation.Semantic proximity Read ↗

Breast cancer patients with p53 Pro72 homozygous genotype have a poorer survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.