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Article

Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer.

Cancer letters - 16 Jul 2004

Granja Fabiana, Morari Joseane, Morari Elaine C, Correa Luiz A C, Assumpção Lígia V M, Ward Laura S

Abstract excerpt

A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72. The resulting codon 72 variants have been reported associated with tumor susceptibility since they reduce p53 ability to activate apoptosis. Codon 72 polymorphism may play a role in subside vulnerability to different carcinogens and might account for ethnic variations in cancer frequency. Using an...

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Identifiers

PMID: 15183530
DOI: 10.1016/j.canlet.2004.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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