Low-dose simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB

Abstract excerpt

<title>Abstract</title> <p>Pancreatic cancer is typically accompanied by fibrosis, forming a dense stromal matrix. This dense matrix restricts drug penetration, making it difficult for drugs to effectively reach tumor cells. Additionally, pancreatic cancer has inadequate local blood supply and "vascular irregularity," which makes it challenging for drugs to reach the core of the tumor. Even if some drugs reach th...

Topics

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• Cancer, Hypoxia, and Metabolism
• Cancer, Lipids, and Metabolism
• Carcinoma, Pancreatic Ductal
• Cell Death
• Ferroptosis
• Mutation
• Pancreatic and Hepatic Oncology Research
• Pancreatic Neoplasms

Identifiers and source

Literature Corpus work

51650c74-9a8e-5bcb-a5d8-c611ea5111c7

DOI

10.21203/rs.3.rs-7657011/v1