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Article

Systematic structure-activity analysis of microcin J25.

The Journal of biological chemistry - 12 Sept 2008

Pavlova Olga, Mukhopadhyay Jayanta, Sineva Elena, Ebright Richard H, Severinov Konstantin

Abstract excerpt

Microcin J25 (MccJ25) is a 21-residue plasmid-encoded ribosomally synthesized lariat-protoknot antibacterial peptide that targets bacterial RNA polymerase. MccJ25 consists of an 8-residue cycle followed by a 13-residue tail that loops back and threads through the cycle. We have performed systematic mutational scanning of MccJ25, constructing and analyzing more than 380 singly substituted derivatives of MccJ25....

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Source

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Identifiers

PMID: 18632663
DOI: 10.1074/jbc.M803995200
PMCID: PMC2533079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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