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Article

Population stratification bias in the case-only study for gene-environment interactions.

American journal of epidemiology - 15 Jul 2008

Wang Liang-Yi, Lee Wen-Chung

Abstract excerpt

The case-only study is a convenient approach and provides increased statistical efficiency in detecting gene-environment interactions. The validity of a case-only study hinges on one well-recognized assumption: The susceptibility genotypes and the environmental exposures of interest are independent in the population. Otherwise, the study will be biased. The authors show that hidden stratification in the study...

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Identifiers

PMID: 18497429
DOI: 10.1093/aje/kwn130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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