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Article

KRAS genotyping in rectal adenocarcinoma specimens with low tumor cellularity after neoadjuvant treatment.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2012

Boissière-Michot Florence, Lopez-Crapez Evelyne, Frugier Hélène, Berthe Marie-Laurence, Ho-Pun-Cheung Alexandre, Assenat Eric, Maudelonde Thierry, Lamy Pierre-Jean, Bibeau Frédéric

Abstract excerpt

KRAS status assessment is mandatory in patients with metastatic colorectal cancer before therapy with anti-epidermal growth factor receptor monoclonal antibodies, as KRAS mutations are associated with resistance to this treatment. However, KRAS genotyping may be very challenging in case of poor tumor cellularity, particularly when major tumor regression is achieved in locally advanced rectal adenocarcinomas after...

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Identifiers

PMID: 22282307
DOI: 10.1038/modpathol.2011.210

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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