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Article

KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jan 2010

Gaedcke Jochen, Grade Marian, Jung Klaus, Schirmer Markus, Jo Peter, Obermeyer Christoph, Wolff Hendrik A, Herrmann Markus K, Beissbarth Tim, Becker Heinz, Ried Thomas, Ghadimi Michael

Abstract excerpt

BACKGROUND AND PURPOSE: KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established. MATERIALS AND METHODS: DNA was isolated from pre-therapeutic biopsies of 94 patients who were treated within two phase-III clinical trials receiving...

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Identifiers

PMID: 19913317
DOI: 10.1016/j.radonc.2009.10.001
PMCID: PMC7373270

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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