KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.

doi:10.1016/j.radonc.2009.10.001

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Article

KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jan 2010

Gaedcke Jochen, Grade Marian, Jung Klaus, Schirmer Markus, Jo Peter, Obermeyer Christoph, Wolff Hendrik A, Herrmann Markus K, Beissbarth Tim, Becker Heinz, Ried Thomas, Ghadimi Michael

Abstract excerpt

BACKGROUND AND PURPOSE: KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. However, data specifically for locally advanced rectal cancers are scarce, and the frequency of KRAS mutations in codons 61 and 146 remains to be established. MATERIALS AND METHODS: DNA was isola...

Topics

Adult
Aged
Aged, 80 and over
Biopsy, Needle
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Mutation
Preoperative Care
Proto-Oncogene Proteins
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rectal Neoplasms

Treatment Outcome

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19913317
DOI: 10.1016/j.radonc.2009.10.001
PMCID: PMC7373270

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19913317-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.