Characterization of KRAS Mutational Regression in Oligometastatic Patients.

doi:10.3389/fimmu.2022.898561

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Article

Characterization of KRAS Mutational Regression in Oligometastatic Patients.

Frontiers in immunology - 1 Jan 2022

Ottaiano Alessandro, de Vera d'Aragona Roberta Penta, Trotta Anna Maria, Santorsola Mariachiara, Napolitano Maria, Scognamiglio Giosuè, Tatangelo Fabiana, Grieco Paolo, Zappavigna Silvia, Granata Vincenza, Perri Francesco, Luce Amalia, Savarese Giovanni, Ianniello Monica, Casillo Marika, Petrillo Nadia, Belli Andrea, Izzo Francesco, Nasti Guglielmo, Caraglia Michele, Scala Stefania

Abstract excerpt

Background: We previously reported rare regressive genetic trajectories of KRAS pathogenic mutations as a specific hallmark of the genuine oligometastatic status in colorectal cancer (CRC). Methods: Survival and prognostic impact of disease extent in 140 metastatic CRC patients were evaluated through the Kaplan-Meyer curves and the Log-Rank test. KRAS mutations were assessed through the Illumina NovaSeq 6000...

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Identifiers

PMID: 35936004
DOI: 10.3389/fimmu.2022.898561
PMCID: PMC9354788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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