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Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: therapeutic implications

20 Apr 2023

Abstract excerpt

The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells’ survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell resistance to cytotoxic drugs/cells. Likewise, the tumor suppressor, phosphatase and tensin homolog (PTEN), which inhibits the phosphatidylinositol 3 kinase...

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PMID: 37205308
DOI: 10.37349/etat.2023.00128

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