Article
Links between DNA double strand break repair and breast cancer: accumulating evidence from both familial and nonfamilial cases.
Cancer letters - 8 Apr 2007
Ralhan Ranju, Kaur Jatinder, Kreienberg Rolf, Wiesmüller Lisa
Abstract excerpt
DNA double strand break (DSB) repair dysfunction increases the risk of familial and sporadic breast cancer. Advances in the understanding of genetic predisposition to breast cancer have also been made by screening naturally occurring polymorphisms. These studies revealed that subtle defects in DNA repair capacity arising from low-penetrance genes, or combinations thereof, are modified by other genetically...
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