Article
Growth hormone receptor exon 3 isoforms and their implication in growth disorders and treatment.
Hormone research - 1 Apr 2009
Jorge Alexander A L, Arnhold Ivo J P
Abstract excerpt
Human recombinant growth hormone (hGH) has been used to treat short stature in several different conditions, but considerable inter-individual variation in short- and long-term growth response exists. Pharmacogenomics can provide important insights into hGH therapy. The GH receptor (GHR) is the first key molecule mediating GH action. In the past 3 years, a common GHR polymorphism reflecting the presence (GHRfl)...
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