Article
Homozygosity of the d3-growth hormone receptor polymorphism is associated with a high total effect of GH on growth and a low BMI in girls with Turner syndrome.
Clinical endocrinology - 1 Apr 2008
Binder Gerhard, Trebar Branko, Baur Friederike, Schweizer Roland, Ranke Michael B
Abstract excerpt
OBJECTIVE: The protein polymorphism of the GH receptor caused by genomic deletion of exon 3 (d3) has been linked to the magnitude of the first-year-growth response to GH in girls with Turner syndrome. Here, we studied the long-term effect of GH therapy in Turner syndrome in correlation to this polymorphism. DESIGN: The study was mainly retrospective. PATIENTS: The women with Turner syndrome (n = 48) had been...
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