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Article

The Effect of Thiazide Diuretics on Urinary Prostaglandin E2 Excretion and Serum Sodium in the General Population.

The Journal of clinical endocrinology and metabolism - 16 Sept 2024

Geurts Frank, Rudolphi Crissy F, Pelouto Anissa, van der Burgh Anna C, Salih Mahdi, Imenez Silva Pedro Henrique, Fenton Robert A, Chaker Layal, Hoorn Ewout J

Abstract excerpt

CONTEXT: Thiazide-induced hyponatremia is one of the most common forms of hyponatremia, but its pathogenesis is incompletely understood. Recent clinical data suggest links with prostaglandin E2 (PGE2) and a single nucleotide polymorphism (SNP) in the prostaglandin transporter gene (SLCO2A1), but it is unknown if these findings also apply to the general population. OBJECTIVE: To study the associations between...

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Identifiers

PMID: 38776231
DOI: 10.1210/clinem/dgae352
PMCID: PMC11403316

Genes

SLCO2A1

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