Article
Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.
The Journal of clinical investigation - 1 Sept 2017
Ware James S, Wain Louise V, Channavajjhala Sarath K, Jackson Victoria E, Edwards Elizabeth, Lu Run, Siew Keith, Jia Wenjing, Shrine Nick, Kinnear Sue, Jalland Mahli, Henry Amanda P, Clayton Jenny, O'Shaughnessy Kevin M, Tobin Martin D, Schuster Victor L, Cook Stuart, Hall Ian P, Glover Mark
Abstract excerpt
Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse effect, is poorly understood. Here, we have studied the phenotypic and genetic characteristics of patients hospitalized with TIH. In a cohort of 109 TIH patients, those with severe TIH displayed an extended phenotype of intravascular volume expansion, increased...
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