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Article

Family-B G-protein-coupled receptors.

Genome biology - 1 Jan 2001

Harmar A J

Abstract excerpt

SUMMARY: All G-protein-coupled receptors (GPCRs) share a common molecular architecture (with seven putative transmembrane segments) and a common signaling mechanism, in that they interact with G proteins (heterotrimeric GTPases) to regulate the synthesis of intracellular second messengers such as cyclic AMP, inositol phosphates, diacylglycerol and calcium ions. Historically, GPCRs have been classified into six...

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Identifiers

PMID: 11790261
DOI: 10.1186/gb-2001-2-12-reviews3013
PMCID: PMC138994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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