Article
Family-B G-protein-coupled receptors.
Genome biology - 1 Jan 2001
Harmar A J
Abstract excerpt
SUMMARY: All G-protein-coupled receptors (GPCRs) share a common molecular architecture (with seven putative transmembrane segments) and a common signaling mechanism, in that they interact with G proteins (heterotrimeric GTPases) to regulate the synthesis of intracellular second messengers such as cyclic AMP, inositol phosphates, diacylglycerol and calcium ions. Historically, GPCRs have been classified into six...
Topics
- Amino Acid Sequence
- Animals
- Evolution, Molecular
- Heterotrimeric GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Phylogeny
- Protein Structure, Tertiary
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Receptors, Gastrointestinal Hormone
- Sequence Alignment
- Terminology as Topic