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Article

Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease.

Current Alzheimer research - 1 May 2012

Sun Chenyou, Ou Xiaoming, Farley Jerry M, Stockmeier Craig, Bigler Steven, Brinton Roberta Diaz, Wang Jun Ming

Abstract excerpt

More than a third of Alzheimer's disease (AD) patients show nigrostriatal pathway disturbances, resulting in akinesia (inability to initiate movement) and bradykinesia (slowness of movement). The high prevalence of this dysfunction of dopaminergic neuron in the nigrostriatal pathway in AD suggest...

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Identifiers

PMID: 22272610
DOI: 10.2174/156720512800492567
PMCID: PMC3348519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22272610-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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