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Article

Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease.

Journal of neuroscience research - 1 Sept 2015

Melief Erica J, Cudaback Eiron, Jorstad Nikolas L, Sherfield Emily, Postupna Nadia, Wilson Angela, Darvas Martin, Montine Kathleen S, Keene C Dirk, Montine Thomas J

Abstract excerpt

Parkinson's disease and Alzheimer's disease (AD) are recognized to coexist on a spectrum of neurodegeneration, and it has been proposed that molecular interactions among pathogenic proteins are a basis for the overlap between these two diseases. We instead hypothesized that degeneration of the nigrostriatal dopaminergic system enhances the clinical penetrance of early-stage AD. To determine the effect of striatal...

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PMID: 25824456
DOI: 10.1002/jnr.23592
PMCID: PMC4504797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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