Article
Genetic polymorphisms in MMP7 and reduced serum levels associate with the development of bronchiolitis obliterans syndrome after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jun 2010
Kastelijn Elisabeth A, van Moorsel Coline H, Ruven Henk J, Karthaus Vincent, Kwakkel-van Erp Johanna M, van de Graaf Ed A, Zanen Pieter, van Kessel Diana A, Grutters Jan C, van den Bosch Jules M
Abstract excerpt
BACKGROUND: Pulmonary epithelium is the primary target of injury in the development of bronchiolitis obliterans syndrome (BOS) after lung transplantation. Matrix metalloproteinases (MMP)-8 and -9 already have been implicated in the pathogenesis of BOS. MMP-7, which is involved in the repair of the lung epithelium, has not been studied in this respect. We hypothesized that genetic polymorphisms in MMP7 influence...
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