Article
A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode.
Respiratory research - 8 Jun 2011
Ahn Mi-Hyun, Park Byung-Lae, Lee Shin-Hwa, Park Sung-Woo, Park Jong-Sook, Kim Do-Jin, Jang An-Soo, Park Jai-Soung, Shin Hwa-Kyun, Uh Soo-Taek, Kim Yang-Ki, Kim Young Whan, Han Sung Koo, Jung Ki-Suck, Lee Kye Young, Jeong Sung Hwan, Park Jeong Woong, Choi Byoung Whui, Park In Won, Chung Man Pyo, Shin Hyoung Doo, Song Jin Woo, Kim Dong Soon, Park Choon-Sik, Shim Young-Soo
Abstract excerpt
BACKGROUND: Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs) of the IL-8 gene on the risk of IPF. METHODS: One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and...
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