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Article

Functional analysis of the human inhibin alpha subunit variant A257T and its potential role in premature ovarian failure.

Human reproduction (Oxford, England) - 1 Dec 2007

Chand Ashwini L, Ooi Guck T, Harrison Craig A, Shelling Andrew N, Robertson David M

Abstract excerpt

BACKGROUND: A nucleotide substitution in the inhibin alpha subunit (INHA 769G>A, A257T) has been associated with premature ovarian failure (POF). We hypothesize this mutation causes a reduction in inhibin bioactivity, removing its suppression on the pituitary FSH secretion. The aim of this study...

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Source

Identifiers

PMID: 17933751
DOI: 10.1093/humrep/dem323

Genes

INHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17933751-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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