Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes.

Acta pharmacologica Sinica - 1 Mar 2012

Chen Lei-lei, Wu Jun-chao, Wang Lin-hui, Wang Jin, Qin Zheng-hong, Difiglia Marian, Lin Fang

Abstract excerpt

AIM: To investigate the effects of rapamycin on glutamate uptake in cultured rat astrocytes expressing N-terminal 552 residues of mutant huntingtin (Htt-552). METHODS: Primary astrocyte cultures were prepared from the cortex of postnatal rat pups. An astrocytes model of Huntington's disease was established using the astrocytes infected with adenovirus carrying coden gene of N-terminal 552 residues of Huntingtin....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Excitatory Amino Acid Transporter 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Nerve Tissue Proteins

Share to Nuclear Proteins

Share to Rats, Sprague-Dawley

Share to Sirolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 22266730
DOI: 10.1038/aps.2011.162
PMCID: PMC4077128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes.PMID 22266730Read ↗

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Semantic proximity Read ↗

Glutamine Synthetase-1 induces autophagy-lysosomal degradation of huntingtin aggregates and ameliorates animal motility in a <i>Drosophila</i> model for Huntington’s diseaseSemantic proximity Read ↗

Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington's Disease.Semantic proximity Read ↗

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytesSemantic proximity Read ↗

Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.Semantic proximity Read ↗

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.Semantic proximity Read ↗

Methylmercury alters the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.Semantic proximity Read ↗

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3.Semantic proximity Read ↗

High efficiency adenovirus-mediated expression of truncated N-terminal huntingtin fragment (htt552) in primary rat astrocytes.Semantic proximity Read ↗

CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1.Semantic proximity Read ↗

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Semantic proximity Read ↗

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.