Article
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
BMC neuroscience - 18 Feb 2010
Sadasivan Shankar, Zhang Zhiqun, Larner Stephen F, Liu Ming C, Zheng Wenrong, Kobeissy Firas H, Hayes Ronald L, Wang Kevin K W
Abstract excerpt
BACKGROUND: Autophagy, an intracellular response to stress, is characterized by double membrane cytosolic vesicles called autophagosomes. Prolonged autophagy is known to result in autophagic (Type II) cell death. This study examined the potential role of an autophagic response in cultured cerebel...
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