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Article

Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA Breaks

1 Aug 2001

Abstract excerpt

ATM mutations are responsible for the genetic disease ataxia-telangiectasia (A-T). ATM encodes a protein kinase that is activated by ionizing radiation-induced double strand DNA breaks. Cells derived from A-T patients show many abnormalities, including accelerated telomere loss and hypersensitivity to ionizing radiation; they enter into mitosis and apoptosis after DNA damage. Pin2 was originally identified as a...

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PMID: 11375976
DOI: 10.1074/jbc.m011534200

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Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA BreaksPMID 11375976Read ↗

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