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Article

A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk.

PLoS medicine - 1 Oct 2005

Reitsma Pieter H, van der Heijden Jeroen F, Groot Angelique P, Rosendaal Frits R, Büller Harry R

Abstract excerpt

BACKGROUND: A C1173T polymorphism in intron 1 of the VKORC1 gene has been claimed to determine the interindividual variability in the response to vitamin K antagonist therapy (VKA), but it is unknown whether it also influences bleeding risk. We aimed to confirm the relationship between C1173T sta...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16201835
DOI: 10.1371/journal.pmed.0020312
PMCID: PMC1251635

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16201835-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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