Article
Infiltration of Lynch colorectal cancers by activated immune cells associates with early staging of the primary tumor and absence of lymph node metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2012
de Miranda Noel F C C, Goudkade Danny, Jordanova Ekaterina S, Tops Carli M J, Hes Frederik J, Vasen Hans F A, van Wezel Tom, Morreau Hans
Abstract excerpt
PURPOSE: Lynch syndrome colorectal cancers often lose human leukocyte antigen (HLA) class I expression. The outgrowth of clones with immune evasive phenotypes is thought to be positively selected by the action of cytotoxic T cells that target HLA class I-positive cancer cells. To investigate this hypothesis, we related the type and density of tumor lymphocytic infiltrate in Lynch colorectal cancers with their HLA...
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