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Article

Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic

27 Feb 2004

Abstract excerpt

BACKGROUND: Patients with colorectal cancer that display high-level microsatellite instability (MSI-H) appear to have a better prognosis. This may be explained by the pronounced T cell infiltrate seen in MSI-H tumours that is related to a specific antigen-driven immune response. The nature of tumour-infiltrating lymphocytes in colorectal cancers was investigated using quantitative real-time polymerase chain...

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PMID: 15048750
DOI: 10.1002/bjs.4472

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