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Article

Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.

Cancer immunology, immunotherapy : CII - 1 Mar 2015

Surmann Eva-Maria, Voigt Anita Y, Michel Sara, Bauer Kathrin, Reuschenbach Miriam, Ferrone Soldano, von Knebel Doeberitz Magnus, Kloor Matthias

Abstract excerpt

Besides being expressed on professional antigen-presenting cells, HLA class II antigens are expressed on various tumors of non-lymphoid origin, including a subset of colorectal cancers (CRC). Information about the regulation of HLA class II antigen expression is important for a better understanding of their role in the interactions between tumor and immune cells. Whether lack of HLA class II antigen expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25445815
DOI: 10.1007/s00262-014-1638-4
PMCID: PMC8711774

Genes

CD4
CIITA

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