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Article

Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients.

Science translational medicine - 18 Jan 2012

Clark Rachael A, Watanabe Rei, Teague Jessica E, Schlapbach Christoph, Tawa Marianne C, Adams Natalie, Dorosario Andrew A, Chaney Keri S, Cutler Corey S, Leboeuf Nicole R, Carter Joi B, Fisher David C, Kupper Thomas S

Abstract excerpt

Cutaneous T cell lymphoma (CTCL) is a cancer of skin-homing T cells with variants that include leukemic CTCL (L-CTCL), a malignancy of central memory T cells (T(CM)), and mycosis fungoides (MF), a malignancy of skin resident effector memory T cells (T(EM)). We report that low-dose alemtuzumab (αCD52) effectively treated patients with refractory L-CTCL but not MF. Alemtuzumab depleted all T cells in blood and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22261031
DOI: 10.1126/scitranslmed.3003008
PMCID: PMC3373186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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