Article
Phenotypic heterogeneity of mycosis fungoides cells leads to the difficulties in determining tumour origin.
The Australasian journal of dermatology - 1 Aug 2024
Jin Sha, Zhao Yige, Wang Shiwen, Wang Panpan, Tang Chenyu, Zhu Mengyan, Wang Ping
Abstract excerpt
Mycosis fungoides (MF) is a low-grade malignant cutaneous T-cell lymphoma that originates from memory T cells. It typically follows a unique and relatively indolent disease course. MF is used to be characterized by a tissue-resident memory T cell (TRM) phenotype, although recent molecular research has revealed its complexity, casting doubt on the cell of origin and the TRM-MF paradigm. Recent clonal heterogeneity...
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