Article
The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders.
Frontiers in immunology - 1 Jan 2021
de Jesús-Gil Carmen, Sans-de SanNicolàs Lídia, García-Jiménez Irene, Ferran Marta, Celada Antonio, Chiriac Anca, Pujol Ramon M, Santamaria-Babí Luis F
Abstract excerpt
Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface. CLA+ memory T cells not only migrate from blood to skin but also recirculate between blood and skin. Studying CLA+ memory T cells in cutaneous diseases has allowed a better understanding of immune-inflammatory mechanisms that take place....
Topics
- Biomarkers
- Dermatitis
- Diagnosis, Differential
- Humans
- Immunologic Memory
- Immunophenotyping
- Lymphocyte Count
- Phenotype
- Receptors, Immunologic
- T-Lymphocyte Subsets