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Article

Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species.

Biochemical and biophysical research communications - 10 Feb 2012

Kuang Xianghong, Yan Mingshan, Ajmo Joanne M, Scofield Virginia L, Stoica George, Wong Paul K Y

Abstract excerpt

Ataxia telangiectasia (A-T) is an inherited disease, the most prominent feature of which is ataxia caused by degeneration of cerebellar neurons and synapses. The mechanisms underlying A-T neurodegeneration are still unclear, and many factors are likely to be involved. AMP-activated protein kinase (AMPK) is a sensor of energy balance, and research on its function in neural cells has gained momentum in the last...

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Identifiers

PMID: 22260947
DOI: 10.1016/j.bbrc.2012.01.008
PMCID: PMC4109361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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