ATM-kinase deficiency triggers early multi-compartment remodeling of the cerebellar microenvironment

Abstract excerpt

<title>Abstract</title> <p> Ataxia Telangiectasia (A-T) is a neurodegenerative disorder characterized by early onset, cerebellar ataxia and progressive motor decline. The causative gene, <italic>ATM</italic> (A-T Mutated), encodes a Ser/Thr kinase, that belongs to the phosphoinositide 3-kinase-related protein kinase family and is crucial for the response to DNA double-strand breaks. While ATM is classically kn...

Topics

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• Ataxia Telangiectasia
• Ataxia Telangiectasia Mutated Proteins
• DNA Repair
• DNA Repair Mechanisms
• Mutation
• Oxidative Stress
• Phenotype
• Signal Transduction

Identifiers and source

Literature Corpus work

bcb7f8dd-f268-539f-a995-088073be38f5

DOI

10.21203/rs.3.rs-8832557/v1