Article

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

2018-09-11

Abstract excerpt

We have uncovered new insights into the symptoms of ataxia-telangiectasia (A-T). Neurons with high physiological activity, particularly cerebellar Purkinje cells, have large and dynamic ATP demands. Depletion of ATP generates reactive oxygen species that activate ATM (the A - T M utated gene product). Activated in this way, but not by DNA damage, ATM phosphorylates nuclear respiratory factor-1 (NRF1). This leads...

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Literature Corpus work: 79720fb5-05a3-5324-ab97-3ace04edcbce
DOI: 10.1101/414490

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