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Article

Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.

Toxicology and applied pharmacology - 15 Jul 2008

Jain Meenu, Tilak Anup Raj, Upadhyay Rohit, Kumar Ashwani, Mittal Balraj

Abstract excerpt

Genetic polymorphisms in xenobiotic metabolizing enzymes may alter risk of various cancers. Present case-control study evaluated the influence of EPHX1 genetic variations on squamous cell esophageal cancer (ESCC) susceptibility in 107 patients and 320 controls. EPHX1 polymorphic alleles were geno...

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Source

Identifiers

PMID: 18406439
DOI: 10.1016/j.taap.2008.02.023

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18406439-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.PMID 18406439Read ↗

Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.Semantic proximity Read ↗

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis.Semantic proximity Read ↗

Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.Semantic proximity Read ↗

EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.Semantic proximity Read ↗

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk.Semantic proximity Read ↗

Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.Semantic proximity Read ↗

Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India.Semantic proximity Read ↗

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Association between head and neck cancer and microsomal epoxide hydrolase genotypes.Semantic proximity Read ↗

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.Semantic proximity Read ↗

Genetically lowered microsomal epoxide hydrolase activity and tobacco-related cancer in 47,000 individuals.Semantic proximity Read ↗

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