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Article

Physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1.

Biochemistry - 21 Feb 2012

Hyun Moonjung, Park Sojin, Kim Eunsun, Kim Do-Hyung, Lee Se-Jin, Koo Hyeon-Sook, Seo Yeon-Soo, Ahn Byungchan

Abstract excerpt

The Caenorhabditis elegans Werner syndrome protein, WRN-1, a member of the RecQ helicase family, has a 3'-5' DNA helicase activity. Worms with defective wrn-1 exhibit premature aging phenotypes and an increased level of genome instability. In response to DNA damage, WRN-1 participates in the initial stages of checkpoint activation in concert with C. elegans replication protein A (RPA-1). WRN-1 helicase is...

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Source

Identifiers

PMID: 22257160
DOI: 10.1021/bi200791p

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1.PMID 22257160Read ↗

Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans.Semantic proximity Read ↗

A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint.Semantic proximity Read ↗

p53 Modulates RPA-Dependent and RPA-Independent WRN Helicase ActivitySemantic proximity Read ↗

The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.Semantic proximity Read ↗

Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro.Semantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.Semantic proximity Read ↗

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrestSemantic proximity Read ↗

Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repairSemantic proximity Read ↗

Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration ActivitySemantic proximity Read ↗

Dissection of functional domains of the human DNA replication protein complex replication protein A.Semantic proximity Read ↗

DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities.Semantic proximity Read ↗

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