Article
Transcriptional repression by a bZIP protein regulates Dictyostelium prespore differentiation.
PloS one - 1 Jan 2012
Nuñez-Corcuera Beatriz, Birch Joanna L, Yamada Yoko, Williams Jeffrey G
Abstract excerpt
In response to the signaling polyketide DIF-1 DimB directly activates transcription of the ecmB gene in pstB cells; a subset of the prestalk cells that are the precursors of the basal disc. We show that the promoter of pspA, a prespore-specific gene, also contains a DimB binding site. Mutation of this site causes ectopic expression in the prestalk region and ChIP analysis shows that DIF-1 induces binding of DimB...
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