DIF-1 regulates Dictyostelium basal disc differentiation by inducing the nuclear accumulation of a bZIP transcription factor.

doi:10.1016/j.ydbio.2011.03.024

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Article

DIF-1 regulates Dictyostelium basal disc differentiation by inducing the nuclear accumulation of a bZIP transcription factor.

Developmental biology - 1 Jun 2011

Yamada Yoko, Nuñez-Corcuera Beatriz, Williams Jeffrey G

Abstract excerpt

Exposure of monolayer Dictyostelium cells to the signalling polyketide DIF-1 causes DimB, a bZIPtranscription factor, to accumulate in the nucleus where it induces prestalk gene expression. Here we analyse DimB signalling during normal development. In slugs DimB is specifically nuclear enriched in the pstB cells; a cluster of vital dye-staining cells located on the ventral surface of the posterior, prespore...

Topics

Animals
Basic-Leucine Zipper Transcription Factors
Cell Differentiation
Cell Nucleus
Chromatin Immunoprecipitation
Dictyostelium
Extracellular Matrix Proteins
Gene Expression
Green Fluorescent Proteins
Hexanones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Confocal

Movement

Mutation

Protein Binding

Protozoan Proteins

Reverse Transcriptase Polymerase Chain Reaction

Signal Transduction

Source

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Identifiers

PMID: 21458438
DOI: 10.1016/j.ydbio.2011.03.024
PMCID: PMC3107940

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