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Article

CTLA-4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer.

The journal of obstetrics and gynaecology research - 1 May 2022

Chen Juan, Kang Shan, Wu Jianlei, Zhao Jian, Si Wengang, Sun Haiyan, Li Yan

Abstract excerpt

AIM: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), an inhibitory molecule on T-cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA-4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patients. METHODS: A case-control study was performed in 527 epithelial ovarian cancer patients and 532 controls....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35150042
DOI: 10.1111/jog.15186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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