Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models.

Investigative ophthalmology & visual science - 1 Mar 2012

Yu Yi, Reynolds Robyn, Rosner Bernard, Daly Mark J, Seddon Johanna M

Abstract excerpt

PURPOSE: Understanding the effect of genes on progression to different stages of age-related macular degeneration (AMD) may suggest stage-specific therapeutic targets and more precise prediction of the development of this disease. METHODS: Progression events and time to each stage of AMD were derived from the longitudinal data of 2560 subjects without advanced AMD. SNPs in 12 AMD risk loci were genotyped. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Disease Progression

Share to Macular Degeneration

Share to Markov Chains

Share to Models, Statistical

Share to Multivariate Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 22247473
DOI: 10.1167/iovs.11-8657
PMCID: PMC3339916

Genes

ABCA1
ARMS2
CFB
CFH
HTRA1
LIPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models.PMID 22247473Read ↗

Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors.Semantic proximity Read ↗

Rare and Common Genetic Variants, Smoking and Higher Body Mass Index Are Associated with Earlier Age of Progression to Geographic Atrophy and Neovascular Advanced Stages of Macular Degeneration in a Prospective AnalysisSemantic proximity Read ↗

Rare and Common Genetic Variants, Smoking, and Body Mass Index: Progression and Earlier Age of Developing Advanced Age-Related Macular Degeneration.Semantic proximity Read ↗

Validation of a prediction algorithm for progression to advanced macular degeneration subtypes.Semantic proximity Read ↗

Genome-wide analysis of disease progression in age-related macular degeneration.Semantic proximity Read ↗

Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates.Semantic proximity Read ↗

Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration.Semantic proximity Read ↗

Risk factors for progression of age-related macular degeneration.Semantic proximity Read ↗

Effect of the Y402H variant in the complement factor H gene on the incidence and progression of age-related macular degeneration: results from multistate models applied to the Beaver Dam Eye Study.Semantic proximity Read ↗

Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading SystemSemantic proximity Read ↗

Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables.Semantic proximity Read ↗

Quantifying Effects of Lifestyle Changes on Progression to Advanced Age-Related Macular Degeneration in High Genetic Risk IndividualsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.