Effect of the Y402H variant in the complement factor H gene on the incidence and progression of age-related macular degeneration: results from multistate models applied to the Beaver Dam Eye Study.

Abstract excerpt

OBJECTIVES: To investigate the effect of age, sex, and the Y402H variant in the complement factor H (CFH) gene on the incidence, progression, and regression of age-related macular degeneration (AMD) as well as the effect of these factors and AMD on mortality, using multistate models. METHODS: Analyses included 4379 persons aged 43 to 84 years at the time of the census. The status of AMD on a 5-level severity...

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