Article
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer research - 15 Jul 2010
Janakiraman Manickam, Vakiani Efsevia, Zeng Zhaoshi, Pratilas Christine A, Taylor Barry S, Chitale Dhananjay, Halilovic Ensar, Wilson Manda, Huberman Kety, Ricarte Filho Julio Cezar, Persaud Yogindra, Levine Douglas A, Fagin James A, Jhanwar Suresh C, Mariadason John M, Lash Alex, Ladanyi Marc, Saltz Leonard B, Heguy Adriana, Paty Philip B, Solit David B
Abstract excerpt
Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor (EGFR)-targeted therapies, limited clinical testing for RAS pathway mutations has recently been adopted. We performed a m...
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