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Article

Senescence: a new weapon for cancer therapy.

Trends in cell biology - 1 Apr 2012

Acosta Juan Carlos, Gil Jesús

Abstract excerpt

Senescence is a stable cell cycle arrest that can be activated by oncogenic signaling and manifests with changes in cellular organization and gene expression, such as the induction of a complex secretome. Importantly, senescence limits tumor progression and determines the outcome of conventional anticancer therapies. In recent years, therapeutic approaches such as p53 reactivation, inhibition of c-MYC in addicted...

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PMID: 22245068
DOI: 10.1016/j.tcb.2011.11.006

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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