Article
Rescue of the murine amelogenin null phenotype with two amelogenin transgenes.
European journal of oral sciences - 1 Dec 2011
Gibson Carolyn W, Li Yong, Suggs Cynthia, Kuehl Melissa A, Pugach Megan K, Kulkarni Ashok B, Wright John T
Abstract excerpt
The amelogenin proteins are required for normal enamel development, and the most abundant amelogenins expressed from alternatively spliced mRNAs are M180 and leucine-rich amelogenin protein (LRAP). The X-Chromosomal Amelogenin (Amelx) null [knockout (KO)] mouse has an enamel defect similar to human X-linked amelogenesis imperfecta. The disorganized enamel layer in KO mice is 10-20% of the thickness of wild-type...
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