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Article

The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype.

Cells, tissues, organs - 1 Jan 2009

Gibson Carolyn W, Li Yong, Daly Bill, Suggs Cynthia, Yuan Zhi-an, Fong Hanson, Simmons Darrin, Aragon Melissa, Kulkarni Ashok B, Wright J Timothy

Abstract excerpt

INTRODUCTION: The amelogenin proteins secreted by ameloblasts during dental enamel development are required for normal enamel structure. Amelx null (KO) mice have hypoplastic, disorganized enamel similar to that of human patients with mutations in the AMELX gene, and provide a model system for studies of the enamel defect amelogenesis imperfecta. Because many amelogenin proteins are present in developing enamel...

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Source

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Identifiers

PMID: 18701811
DOI: 10.1159/000151384
PMCID: PMC2824192

Genes

AMELX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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