Article
Tooth enamel defects in mice with a deletion at the Arhgap 6/Amel X locus.
Calcified tissue international - 1 Jul 2005
Prakash S K, Gibson C W, Wright J T, Boyd C, Cormier T, Sierra R, Li Y, Abrams W R, Aragon M A, Yuan Z A, van den Veyver I B
Abstract excerpt
The amelogenin proteins regulate enamel mineral formation in the developing tooth. The human AMELX gene, which encodes the amelogenin proteins, is located within an intron of the Arhgap 6 gene. ARHGAP 6 encodes a Rho GAP, which regulates activity of Rho A, a small G protein involved in intracellular signal transduction. Mice were generated in which the entire ARHGAP 6 gene was deleted by Cre-mediated...
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